Just today, the American Journal of Clinical Nutrition – the most prestigious nutrition journal in the world – published a systematic review and meta-analysis of the paleolithic nutrition pattern (the Paleo diet).
The audio interview below is with study authors, Hanno Pijl, M.D., Ph.D., and Ester van Zuurin, M.D., both of Leiden Unversity in the Netherlands. They, along with authors Eric Manheimer and Zbys Fedorowicz, first performed a systematic review of six online publication libraries for all possible qualifying research. From there, they winnowed the list to four studies, pooling together 159 subjects for their analysis, looking for mean differences in primary endpoints related to metabolic syndrome: 1) Waist circumference, 2) Blood pressure, 3) Triglycerides, 4) HDL cholesterol, and 5) Blood sugar concentration. Secondary endpoints included change in body weight, even though some of the studies included in the analysis tried to prevent weight change so that the results would be less confounded by it. Weight loss, while healthy for someone who is overweight, can also improve these endpoints independently, making it harder to know if it is the nutritional properties of the diet or the weight loss that influenced results. We discuss this specifically in the interview, which you can listen to it here in its entirety.