Aging

Articles

Can We Reverse Aging With “Young Blood?”

Can we stave off the aging process by transfusing young blood into old people? The idea that youthful blood might have rejuvenating properties has lingered in popular imagination for centuries.

In this episode of humanOS Radio, I speak with Drs. Michael and Irina Conboy of the Department of Bioengineering at UC Berkeley. Their lab investigates the process of tissue repair throughout the body and is trying to determine why damaged tissue is not productively repaired as the body ages. In their most recent study, they discovered that molecules in aged blood may actually be interfering with the regenerative process. They are trying to identify these inhibitors, and perhaps find a way to clear them from the blood. Are we on the cusp of a breakthrough to help us stay at our peak abilities for decades longer?


Young Forever? We’re Actually Getting Closer (Interview with Aubrey de Grey)

Can we really stay young forever? This has been a goal of humans since the dawn of time. I know I would like to keep my peak abilities and not see those diminish over the decades. Aging is a subject that I have become increasingly interested in and it’s not necessarily because I’m getting older. Understanding it can help guide how you live, even way before you start to feel old. Plenty of things we can do today can help us live longer by not dying early from disease. Diet and lifestyle make a huge difference here, but this podcast is really about something entirely different – it’s about using cutting edge biotechnology to actually keep the aging process at bay far beyond what good lifestyle practices could achieve. We’re talking about staying close to your peak abilities in life through the age of 130 to 150, or even longer.


How Olive Oil Keeps Your Blood Vessels Healthy

We’ve known for a long time that people who consume more olive oil – as opposed to other sources of dietary fat – are protected in certain ways from heart disease. And some recent research has started to uncover the reasons why.

One compelling and unappreciated way that olive oil prevents cardiovascular disease has to do with its impact on blood pressure.

High blood pressure is often characterized as a “silent killer” because it can cause permanent damage throughout the body without any obvious symptoms. Tragically, by the time the problem becomes obvious, it is sometimes too late to reverse the damage.
About 70 million adults in the US have hypertension – that’s 1 in every 3! And only around 52% of people with hypertension have it under control. It is also likely that many are walking around with the condition who don’t even know they have it.

In this post, we will discuss why consuming extra virgin olive oil seems to help keep blood pressure in check – and how you can best take advantage of this in your own diet.


Lifestyle Modifications to Extend Life by Limiting Growth

Does the ideal diet change across the lifespan? I couldn’t help circling back to this idea regularly while writing this article. In the last article on this subject of growth promotion and better aging, we discussed the concept of antagonistic pleotropy, which suggests that natural selection may favor genes that increase reproductive potential – even at the expense of long-term vitality and longevity. But can we harness an understanding of this idea to alter how we live in our post-reproductive window, to stay younger and live longer? In my latest post, I address just that – lifestyle modifications that may not only be effective to help us surviving longer, but also to live better along the way.



Top Health News This Week (May 7-20, 2016)

Every day, we collect the most interesting health and biology news out there, and post it on our Facebook Fan Page and on Twitter. But news and social media move fast, and it’s hard to keep up with everything that comes out every day. Here is a handy roundup of all of the most compelling stories we encountered this week – in case you missed something awesome.

This week, we covered information related to 1) nutrition, 2) sleep & circadian rhythms, 3) physical activity, and 4) aging, fasting & inflammation.


Hot Sauce For Cancer Prevention (and more)

Chili pepper is a culinary element consumed worldwide, especially in China, Mexico, and Italy. Capsaicin is a biologically active alkaloid produced by chili peppers that produce their spicy flavor. The irritation produced by these plants is probably a protective mechanism, evolved to deter animals (like us) from devouring them. But ironically, these compounds, which ostensibly emerged to harm us, may actually offer certain health benefits when eaten – like with respect to cancer.


Get a 10-15% Increase in Lifespan from This Easter Island Substance?

In 1972, a compound was identified from a bacterial species (Streptomyces hygroscopicus) originally found off the coast of Chile on Easter Island. The compound was developed to prevent fungal infections but later was found to do other things like suppressing the immune system. In fact, a primary use for it currently is to prevent organ rejection in transplant patients. It’s possible, however, that its primary use may change in not-too-distant future to something very different due to another feature: This compound also limits cell division (antiproliferation effects) and promotes an intracellular clean up process, immediately raising interest in the field of aging sciences.

The compound is called rapamycin. All of its effects listed above happen through the suppression of a biochemical pathway that it’s named after – the “mechanistic target of rapamycin”, or mTOR for short. Let’s first discuss the mTOR pathway, why it’s so important for aging, and then we’ll take a closer look at the anti-aging properties observed with the compound rapamycin. We’ll also discuss whether this is something you can benefit from now.



How Much Alcohol Should I Drink to Age Better? (Age Better Today, Part 4)

The research on alcohol and its effects on long-term health in humans can appear confusing and seemingly paradoxical. Conventional health organizations recommend moderate drinking – if you drink at all – due to potential beneficial effects for cardiometabolic health. On the other hand, they do not encourage teetotalers to start drinking, on account of the possible risks associated with alcohol consumption.

One basic principle of toxicology to keep in mind is “the dose makes the poison.” This applies to literally all chemicals – including vitamins and minerals that are essential to our survival. Even water can become toxic when too much is absorbed into the body. So, whether or not a substance can be characterized as a toxin is not a simple question. It depends upon the dose, as well as the duration of exposure. Epidemiology and basic science have suggested that alcohol can actually be beneficial to health and longevity – however only in the right amounts. Ethanol appears to work its magic by improving, among other things, insulin sensitivity and lipid profiles. But these benefits are largely lost in the context of heavy drinking. But new research looks at how various levels of daily alcohol consumption influences biological aging. Read more to find out what they discovered.