General Health

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Get a 10-15% Increase in Lifespan from This Easter Island Substance?

In 1972, a compound was identified from a bacterial species (Streptomyces hygroscopicus) originally found off the coast of Chile on Easter Island. The compound was developed to prevent fungal infections but later was found to do other things like suppressing the immune system. In fact, a primary use for it currently is to prevent organ rejection in transplant patients. It’s possible, however, that its primary use may change in not-too-distant future to something very different due to another feature: This compound also limits cell division (antiproliferation effects) and promotes an intracellular clean up process, immediately raising interest in the field of aging sciences.

The compound is called rapamycin. All of its effects listed above happen through the suppression of a biochemical pathway that it’s named after – the “mechanistic target of rapamycin”, or mTOR for short. Let’s first discuss the mTOR pathway, why it’s so important for aging, and then we’ll take a closer look at the anti-aging properties observed with the compound rapamycin. We’ll also discuss whether this is something you can benefit from now.



Age Better Today. Is This Really Possible? (Part 1)

We age every moment we are alive. But the process of aging appears different depending on where one sits on the curve of life. When we are young, aging develops us. When we are old, aging diminishes our abilities. But aging begins before its effects are apparent. It’s just that we’re more likely to care about it when it’s evident. The desire within humans to avoid the perils of biological aging is as old as time itself, but now aging is a field of scientific inquiry, and the promise of extraordinary solutions is imminent. One big aim of this field is to find ways to extend lifespan. Just as interesting, if not more so, is to find strategies that preserve abilities for the duration of the lifespan. This article is the first in a series to address both.


How to design health for life (video)

This may seem like a strange question, but have you ever wondered if the makers of your health apps design their products based on a clear idea about how it helps you achieve health? This video of my presentation at the HxRefactored conference in Boston, which was released today, describes the thesis upon which we base the design of our entire health-supporting ecosystem. As a member of our community, I encourage you to give it a look and add comments below.


What Your Doctor Isn’t Thinking About (Dragging Medical Professionals Into the Modern Era)

The other day I came across this alarming video of what it’s like to drive in Poland. My first thought after watching the clip was “What’s the Toxoplasmosis gondii infection rate in Poland?” T. gondii is a brain parasite easily acquired from eating undercooked meat, or contact with cats, and is associated with a six-fold increase in traffic accidents (this association has been replicated a number of times, in different countries). Well, I looked it up, and found that the latent infection rate in 2003 was around 41% (at least among pregnant women). That’s quite high — in the U.S. the infection rate is only about 11%.

Is there anything to my hypothesis that terrible driving in Poland is related to the relatively high T. gondii infection rate? Probably not. The accident fatality rate in Poland is relatively high for a modern industrialized country. But France has a very low accident fatality rate, and a much higher rate of T. gondii infection. So while T. gondii might be a contributing factor, it’s probably not the most important variable.

I’m fascinated by latent/chronic biological infections, and how they affect human health and behavior. T. gondii in particular is linked to changes in personality, and even schizophrenia.