In 1972, a compound was identified from a bacterial species (Streptomyces hygroscopicus) originally found off the coast of Chile on Easter Island. The compound was developed to prevent fungal infections but later was found to do other things like suppressing the immune system. In fact, a primary use for it currently is to prevent organ rejection in transplant patients. It’s possible, however, that its primary use may change in not-too-distant future to something very different due to another feature: This compound also limits cell division (antiproliferation effects) and promotes an intracellular clean up process, immediately raising interest in the field of aging sciences.
The compound is called rapamycin. All of its effects listed above happen through the suppression of a biochemical pathway that it’s named after – the “mechanistic target of rapamycin”, or mTOR for short. Let’s first discuss the mTOR pathway, why it’s so important for aging, and then we’ll take a closer look at the anti-aging properties observed with the compound rapamycin. We’ll also discuss whether this is something you can benefit from now.